[Construction]

Michigan Occupational Safety and Health Administration (MIOSHA) and CDC coronavirus graphics. A general duty clause citation carries a fine of up to $7,000. On-site inspections conducted by MIOSHA’s general industry and construction industry enforcement divisions determined 16 employers allegedly committed violations by failing to implement necessary precautions to protect employees from contracting COVID-19. Deficiencies included a lack of health screenings, face coverings, employee training, and overall preparedness plans. The cited employers have 15 working days from receipt of the MIOSHA citations to contest the violations and penalties. Employers must provide proof to MIOSHA that abatement has been completed. A cited employer may choose to enter into a Penalty Reduction Agreement with MIOSHA and agree to abate noted hazards by the abatement date provided within the citation and will receive a 50% reduction in penalties. Through our outreach and education, we are seeing strong implementation of these mitigation measures. It is crucial that employers implement these strategies to protect their employees. The latest MIOSHA citations were issued to the below companies for the following issues: Belle Tire in Woodhaven, MI was fined $4,000 for violations of COVID-19 workplace safety requirements; including not removing an employee from the workplace suspected of having COVID-19, no physical barriers installed, and inadequately training employees on safeguards related to COVID-19. The inspection was initiated in response to an employee complaint, view full citation document . Adrian Urgent Care in Adrian, MI was cited for an other-than-serious violation of COVID-19 workplace safety requirements including not maintaining daily health screenings for all visitor that enter the workplace. The inspection was initiated in response to an employee complaint, view full citation document . Bloxsom Roofing and Siding Company of Traverse City, MI was fined $2,800 for violations of COVID-19 workplace safety requirements for not developing a preparedness and response plan, no documentation of daily health screenings, no disinfectant, no COVID-19 safety coordinator, and no face coverings worn on site. Total penalties, including other workplace violations, were $7,200. The inspection was initiated as a planned-programmed inspection, view full citation document . Bush Brothers Asphalt Paving, Inc. of Farmington Hills, MI was cited for an other-than-serious violation of Coronavirus Disease 2019 Emergency Rules, specifically the lack of a preparedness and response plan.  Total penalties, including other workplace violations, were $400. The inspection was initiated as a planned-programmed inspection, view full citation document . Dana Incorporated in Saint Clair, Michigan, was fined $4,000 for violations of COVID-19 workplace safety requirements including failure to require face coverings when social distancing could not get more be maintained, not contacting the local health department when three known positive COVID-19 cases were detected at the workplace, and not maintaining a record of employee COVID-19 training, daily health screenings, and notification to the local health department of known COVID-19 cases at the workplace. The inspection was initiated as part of the MIOSHA COVID-19 Retail State Emphasis Program, view full citation document . Multi-Shores Development, L.L.C. of Traverse City, MI was fined $1,000 for violations of COVID-19 workplace safety requirements for lack of a preparedness and response plan and no face coverings.  Total penalties, including other workplace violations, were $8,100. The inspection was initiated as a planned-programmed inspection, view full citation document . Allied Gutter Co. of Romulus, MI was cited for an other-than-serious violation of Coronavirus Disease 2019 Emergency Rules, specifically the lack of a preparedness and response plan.  Total penalties, including other workplace violations, were $3,700. The inspection was initiated as a planned-programmed inspection, view full citation document .

https://www.uppermichiganssource.com/2021/02/19/ishpeming-business-among-many-cited-statewide-for-covid-19-workplace-safety-violations/

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[Production]

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To understand the impact of genetic variants that are specific to modern humans, Trujillo et al. performed a genome-wide analysis to identify 61 coding variants in protein-coding genes. Identifying the gene encoding the RNA-binding protein NOVA1 as a top candidate for functional analyses, they introduced the archaic gene variant into human pluripotent stem cells and generated brain organoids. These organoids showed alterations in gene expression and splicing as well as morphology and synaptogenesis, suggesting that this method could be used to explore other genetic changes that underlie the phenotypic traits separating our species from extinct relatives. Current views of human evolution, as supported by the fossil record, indicate that many hominin lineage branches arose, but only one survived to the present. Neanderthals and Denisovans, two of these extinct lineages, are our closest evolutionary relatives and therefore provide the most subtle genetic and phenotypic contrast to our species. Comparison of Neanderthal, Denisovan, and extant human genomes has shown that many humans today carry genes introduced through past admixture events and has allowed enumeration of human-specific genetic differences that may have been important for recent human evolution. Neuro-oncological ventral antigen 1 (NOVA1) includes one of the few protein-coding differences between modern human and archaic hominin genomes that could affect human neurodevelopment. NOVA1 regulates alternative splicing in the developing nervous system and is a master regulator of splicing genes responsible for synapse formation. Altered NOVA1 splicing activity in humans is associated with neurological disorders, underscoring the role of NOVA1 in neural function. Using CRISPR-Cas9 genome-editing technology in human induced pluripotent stem cells (iPSCs), we replaced the modern human allele of the NOVA1 gene with the ancestral allele found in Neanderthals and Denisovans, which contains a single-nucleotide substitution at position 200 that causes an isoleucine-to-valine change. To investigate the functional importance of this amino acid change in humans, we followed iPSC neural development through functional cortical organoids. The reintroduction of the archaic version of NOVA1 into a human genetic background causes changes in alternative splicing in genes involved in neurodevelopment, proliferation, and synaptic connectivity. These changes co-occur with differences in organoid morphology and neural network function, suggesting a functional role for the derived human-specific substitution in NOVA1. Furthermore, cortical organoids carrying the archaic NOVA1 displayed distinct excitatory synaptic changes, which may have led to the observed alterations in neural network development. Collectively, our data suggest that expression of the archaic NOVA1 leads to modified synaptic protein interactions, affects glutamatergic signaling, underlies differences in neuronal connectivity, and promotes higher heterogeneity of neurons regarding their electrophysiological profiles. A subset of genetic changes may underly the phenotypic traits that separate our species from these extinct relatives.

https://science.sciencemag.org/content/371/6530/eaax2537